Liberty City celebrates money and status - a paradise for those who have it, and a living nightmare for those who don't. Johnny, a veteran of The Lost biker gang, becomes embroiled in a vicious turf war with rival gangs for control of the city. Louis, part-time hoodlum and full-time assistant to legendary nightclub manager Tony Prince (aka "Gay Tony"), is struggling with the competing loyalties of his family and friends in a world where everyone has a price. They struggle for survival in a city torn apart by violence and corruption as they live through the devastating consequences of their lives.

The story, like Grand Theft Auto 3, takes place in Liberty City, a city based on New York City in the United States. Players take on the role of Niko Bellic, the game's protagonist, who pursues his long-desired "American Dream" in Liberty City with his cousin Roman Beric.

The background city of the game is Liberty City. The game's protagonist, Niko Bellic, travels alone to Liberty City to join his "wealthy" cousin, who, to his surprise, is all about his cousin's boasting. The two brothers go through a lot of hardships and overcome a lot of difficulties to find the "American dream" story. In order to chase the so-called "American Dream", Nick embraces the ideal in his heart and his "rich" cousin and boards a boat to Liberty City. The boat is loaded with people who are going to Liberty City with Nick, including various supplies. After Nick got off the boat, Roman took Nick back to his house in Liberty City. But obviously, Roman lied, Nick did not see the "rich" cousin, cousin instead owed a lot of money, loan sharks are constantly pressing Roman to pay back the money. Nick saw his cousin now and learned the truth about his cousin, both angry and helpless. For the sake of his own and his cousin's life, Nick began to fight in Liberty City. Liberty City, creating the most densely populated and vibrant urban center in the world. It is both a haven for those whose dreams rise and a hell for those whose dreams fall.

In the single-player mode, the game offers almost 40 hours of main flow and close to 100 hours of total flow including branching missions. If you want players to play an action game for such a long time without getting bored, then the production company has to consider adding many attractive things to the flow of the game.

In the game, many tasks are required to drive a car to chase the enemy. Players without certain driving skills, it is very difficult to start a chase war in the free city. Driving enemies have a high AI, and they will not only speed up and run wildly when being chased by Nick, but also drive into side roads that are not shown in the radar from time to time, and then cross a block instantly. Players in high-speed chase, if there is no certain driving skills, it is easy to let the enemy run away. Even if sometimes catch up with the enemy, players still have to find a way to intercept or hit with the car, or overtake the other side of a tailgate crossbar, or shoot the tires of the enemy car with a gun. All of these require players to have certain skills. Want to be able to show off their skills in the chase war, it seems to have to practice more.

The gun battle is the traditional combat mode in Grand Theft Auto, and is also a beautiful scenery in Liberty City. And the use of the Euphoria physics engine system makes the gun battle mode even more thrilling. Since many of the bunkers can be destroyed, players should be a little more cautious when choosing their hiding spots. For example, hiding behind a car, players should consider the car's ability to withstand, because the car was shot more than one gun is going to explode. And hiding behind a bunker, Nick's shot will become less accurate. The good thing is that the shooting system of this work has been innovated, when Nick and the enemy began the gun battle, press and hold LT can lock the enemy, but also can be aimed at the enemy's head, body, hands, legs and other parts, good shot players in the gun battle can play more outstanding.

Players who frequent the bars in Liberty City will find that there are more things to do in the bars. In addition to drinking and dancing, players can also play three kinds of mini-games in the bar. These are dart throwing, bowling and billiards. Players can experience these mini-games at their leisure time. In short, Liberty City gives players the feeling of being, well, real.